Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.
作者信息
Carroll C D, Johnson T O, Tao S, Lauri G, Orlowski M, Gluzman I Y, Goldberg D E, Dolle R E
机构信息
Department of Biology, Pharmacopeia, Inc., Princeton, NJ 08543, USA.
出版信息
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3203-6. doi: 10.1016/s0960-894x(98)00554-x.
PMID:9873703
Abstract
A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1, P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
摘要
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