Sheppard G S, Florjancic A S, Giesler J R, Xu L, Guo Y, Davidsen S K, Marcotte P A, Elmore I, Albert D H, Magoc T J, Bouska J J, Goodfellow C L, Morgan D W, Summers J B
Department 47J, AP-10, Abbott Laboratory, Abbott Park, Illinois 60064, USA.
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3251-6. doi: 10.1016/s0960-894x(98)00597-6.
A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several compounds of the series were shown to be orally bioavailable.
