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Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues.

作者信息

Nakajima N, Enomoto T, Matsuura N, Ubukata M

机构信息

Biotechnology Research Center, Toyama Prefectural University, Japan.

出版信息

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3331-4. doi: 10.1016/s0960-894x(98)00604-0.

DOI:10.1016/s0960-894x(98)00604-0
PMID:9873729
Abstract

Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on srctsNRK cells than 2 and 3.

摘要

相似文献

1
Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues.
Bioorg Med Chem Lett. 1998 Dec 1;8(23):3331-4. doi: 10.1016/s0960-894x(98)00604-0.
2
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The development of sparsomycin as an anti-tumour drug.sparsomycin作为一种抗肿瘤药物的研发。
Anticancer Drug Des. 1988 Mar;2(4):333-7.
5
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7
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8
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Effect of sparsomycin analogues on the puromycin-peptidyl transferase reaction on ribosomes.稀疏霉素类似物对核糖体上嘌呤霉素 - 肽基转移酶反应的影响。
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