Nakajima Noriyuki, Enomoto Takeshi, Watanabe Takehiro, Matsuura Nobuyasu, Ubukata Makoto
Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.
Biosci Biotechnol Biochem. 2003 Dec;67(12):2556-66. doi: 10.1271/bbb.67.2556.
Facile syntheses of sparsomycin (3) and its four analogues (4-7) based on diastereoselective oxidation of sulfide, sulfenylation, and coupling of 6-methyluracylacryllic acid with monooxodithioacetal amine, are described. Studies on the biological activity of morphological reversion on src(ts)-NRK cells were also carried out.
