Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity.
作者信息
Hatanaka T, Fujita K, Ohsumi K, Nakagawa R, Fukuda Y, Nihei Y, Suga Y, Akiyama Y, Tsuji T
机构信息
Pharmaceutical Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Dec 1;8(23):3371-4. doi: 10.1016/s0960-894x(98)00622-2.
PMID:9873736
Abstract
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.
摘要
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