Ross A K, Dear G L, Dear R B, Margolis J O, Ginsberg B
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
J Clin Anesth. 1998 Dec;10(8):631-5. doi: 10.1016/s0952-8180(98)00098-1.
To determine if 450 micrograms/kg (1.5 times the ED95) of rocuronium would result in a comparable onset with a shorter duration of action when compared with 600 micrograms/kg (2 times the ED95).
Randomized, single-blind study.
Teaching hospital.
85 ASA physical status I and II children ages 2 through 12, undergoing elective surgery with an inhalation induction using halothane.
Group 1 received 600 micrograms/kg rocuronium, and Group 2 received 450 micrograms/kg rocuronium.
The two groups were compared using a Student's t-test, with p < 0.05 significant. The time of onset, or time to 95% suppression of neuromuscular twitch with standard errors, was 140 +/- 13 seconds (range 46 to 365 sec) in Group 1 and 148 +/- 13 seconds (range 82 to 345 sec) in Group 2 (NS = not significant). The times to 25% return of twitch from baseline (T25) in Groups 1 and 2 were 28 +/- 1.5 minutes (range 14 to 45 min) and 26 +/- 1.6 minutes (range 10 to 55 min), respectively (NS). The differences between these two doses in onset of, and recovery from, block were not found to be statistically significant. The results, however, excluded 5% of the higher dose group and 31% of the lower dose group who did not achieve 95% suppression of twitch. Time to maximal suppression of neuromuscular blockade, however, was not statistically significant for the 85 patients with a time of 270 +/- 28 seconds (range 91 to 605 sec) with a mean maximal suppression of 98.7% in Group 1 and 313 +/- 25 seconds (range 91 to 899 sec) with a mean maximal suppression of 93.1% in Group 2.
The two doses of rocuronium did not differ statistically in onset or duration. Rocuronium at 600 micrograms/kg offers more reliability than 450 micrograms/kg in achieving adequate muscle relaxation, and the lower dose may result in a significantly large number of patients who may have inadequate intubating conditions.
确定与600微克/千克（ED95的2倍）相比，450微克/千克（ED95的1.5倍）的罗库溴铵是否会产生起效时间相当但作用持续时间更短的效果。
随机单盲研究。
教学医院。
85例年龄在2至12岁的ASA身体状况I级和II级儿童，接受使用氟烷吸入诱导的择期手术。
第1组接受600微克/千克罗库溴铵，第2组接受450微克/千克罗库溴铵。
两组采用Student's t检验进行比较，p<0.05为有显著差异。第1组起效时间，即达到神经肌肉抽搐抑制95%的时间及标准误差为140±13秒（范围46至365秒），第2组为148±13秒（范围82至345秒）（无显著差异）。第1组和第2组从基线恢复至抽搐25%（T25）的时间分别为28±1.5分钟（范围14至45分钟）和26±1.6分钟（范围10至55分钟）（无显著差异）。未发现这两种剂量在阻滞起效和恢复方面的差异具有统计学意义。然而，结果排除了85例患者中未达到抽搐抑制95%的5%的高剂量组患者和31%的低剂量组患者。对于85例患者，达到神经肌肉阻滞最大抑制的时间无统计学意义，第1组为270±28秒（范围91至605秒），平均最大抑制率为98.7%，第2组为313±25秒（范围91至899秒），平均最大抑制率为93.1%。
两种剂量的罗库溴铵在起效时间或持续时间上无统计学差异。600微克/千克的罗库溴铵在实现充分肌肉松弛方面比450微克/千克更可靠，较低剂量可能导致大量患者插管条件不足。
