Canales J J, Iversen S D
Department of Experimental Psychology, University of Oxford, UK.
Eur J Pharmacol. 1998 Dec 4;362(2-3):111-9. doi: 10.1016/s0014-2999(98)00752-3.
Behavioural evidence has accumulated that supports the hypothesis that specific territories of the striatum contribute differentially to the control of motor behaviours. The present experiments compare the behavioural effects of microinjections of amphetamine (20 microg/0.5 microl) with those elicited by the D2-class dopamine receptor agonist quinpirole (3 microg/0.5 microl) following direct microinjection into three anatomically distinct sectors of the striatum: the nucleus accumbens, the ventrolateral striatum and the anterodorsal striatum. Our findings demonstrate that site-specific behavioural responses are induced by microinjections of amphetamine, but not of quinpirole, into the striatum. Our results suggest that widespread areas of the striatum are implicated in the induction of a syndrome of sedation, yawning and motor inhibition, observed readily following microinjections of quinpirole into the striatum. This evidence supports both homogeneity and segregation of function in the striatum at the behavioural level. Further, the results suggest that the elicitation of site-specific action sequences at the level of the striatum seems to require cooperative interactions between D1-class and D2-class dopamine receptors.
行为学证据不断积累，支持了纹状体的特定区域对运动行为控制有不同贡献这一假说。本实验比较了将苯丙胺（20微克/0.5微升）和D2类多巴胺受体激动剂喹吡罗（3微克/0.5微升）直接微量注射到纹状体三个解剖学上不同的区域：伏隔核、腹外侧纹状体和前背侧纹状体后所引发的行为效应。我们的研究结果表明，向纹状体内微量注射苯丙胺可诱发位点特异性行为反应，而注射喹吡罗则不会。我们的结果表明，将喹吡罗微量注射到纹状体内后容易观察到的镇静、打哈欠和运动抑制综合征的诱发与纹状体的广泛区域有关。这一证据支持了纹状体在行为水平上功能的同质性和分离性。此外，结果表明，在纹状体水平诱发位点特异性动作序列似乎需要D1类和D2类多巴胺受体之间的协同相互作用。
