Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.
作者信息
Keene J D
机构信息
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):5-7. doi: 10.1073/pnas.96.1.5.
Abstract
摘要
相似文献
1
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.Hu在哪里？早期反应基因信使核糖核酸亚群的穿梭。 （不过这段英文表述似乎不太准确和完整，可能影响理解其确切含义）
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):5-7. doi: 10.1073/pnas.96.1.5.
2
Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes.HuR与免疫筛选的核不均一核糖核蛋白（hnRNP）和信使核糖核蛋白（mRNP）复合物中的hnRNP蛋白广泛关联。
Biochim Biophys Acta. 2010 Apr;1804(4):692-703. doi: 10.1016/j.bbapap.2009.11.007. Epub 2009 Nov 18.
3
The double lives of shuttling mRNA binding proteins.穿梭信使核糖核酸结合蛋白的双重作用
Cell. 2000 Jul 21;102(2):135-8. doi: 10.1016/s0092-8674(00)00018-0.
4
HNS, a nuclear-cytoplasmic shuttling sequence in HuR.HNS，HuR中的一个核质穿梭序列。
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15293-8. doi: 10.1073/pnas.95.26.15293.
5
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.HuR和多聚（C）结合蛋白与雄激素受体信使核糖核酸3'非翻译区内一个保守的富含UC基序的新型结合。
J Biol Chem. 2002 Jul 26;277(30):27183-92. doi: 10.1074/jbc.M202883200. Epub 2002 May 13.
6
HuR: post-transcriptional paths to malignancy.HuR：通向恶性肿瘤的转录后途径。
RNA Biol. 2005 Jan;2(1):11-3. doi: 10.4161/rna.2.1.1552. Epub 2005 Jan 19.
7
RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein.富含AU元件结合蛋白HuR（一种ELAV蛋白）对RNA的稳定作用。
EMBO J. 1998 Jun 15;17(12):3461-70. doi: 10.1093/emboj/17.12.3461.
8
Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.HuR在拮抗富含AU元件介导的mRNA去稳定化过程中的高度选择性作用。
Mol Cell Biol. 2002 Oct;22(20):7268-78. doi: 10.1128/MCB.22.20.7268-7278.2002.
9
Nucleocytoplasmic mRNA transport.核质mRNA转运
Results Probl Cell Differ. 2001;34:139-55. doi: 10.1007/978-3-540-40025-7_9.
10
The nuclear nurture and cytoplasmic nature of localized mRNPs.局部mRNA核糖核蛋白颗粒的核内起源与胞质性质
Semin Cell Dev Biol. 2007 Apr;18(2):186-93. doi: 10.1016/j.semcdb.2007.01.002. Epub 2007 Jan 23.
引用本文的文献
1
ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases.ELAV/Hu RNA结合蛋白家族：神经疾病、癌症及其他疾病中的关键调节因子。
RNA Biol. 2025 Dec;22(1):1-11. doi: 10.1080/15476286.2025.2471133. Epub 2025 Mar 20.
2
CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.环状 RNA NUP54 通过促进 HuR 细胞质输出并稳定 BIRC3 mRNA 促进肝细胞癌进展。
Cell Death Dis. 2024 Mar 5;15(3):191. doi: 10.1038/s41419-024-06570-4.
3
HuR as a molecular target for cancer therapeutics and immune-related disorders.HuR 作为癌症治疗和免疫相关疾病的分子靶标。
Adv Drug Deliv Rev. 2022 Sep;188:114442. doi: 10.1016/j.addr.2022.114442. Epub 2022 Jul 8.
4
CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner.环状 RNA THBS1 通过 ceRNA 和 RBP 依赖性方式增加 INHBA mRNA 表达和稳定性促进胃癌进展。
Cell Death Dis. 2022 Mar 25;13(3):266. doi: 10.1038/s41419-022-04720-0.
5
Research progress on RNA-binding proteins in breast cancer.乳腺癌中RNA结合蛋白的研究进展
Oncol Lett. 2022 Apr;23(4):121. doi: 10.3892/ol.2022.13241. Epub 2022 Feb 14.
6
Lung fibrosis is induced in ADAR2 overexpressing mice via HuR-induced CTGF signaling.ADAR2 过表达小鼠通过 HuR 诱导的 CTGF 信号诱导肺纤维化。
FASEB J. 2022 Feb;36(2):e22143. doi: 10.1096/fj.202101511R.
7
SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation.SRI-42127，一种新型小分子 RNA 调节因子 HuR 的抑制剂，可有效减弱脂多糖诱导的神经炎症模型中的神经胶质细胞激活。
Glia. 2022 Jan;70(1):155-172. doi: 10.1002/glia.24094. Epub 2021 Sep 17.
8
Tumor-Associated Antigens (TAAs) for the Serological Diagnosis of Osteosarcoma.肿瘤相关抗原（TAAs）在骨肉瘤血清学诊断中的应用。
Front Immunol. 2021 Apr 30;12:665106. doi: 10.3389/fimmu.2021.665106. eCollection 2021.
9
RNA-Binding Protein HuD as a Versatile Factor in Neuronal and Non-Neuronal Systems.RNA结合蛋白HuD作为神经元和非神经元系统中的多功能因子
Biology (Basel). 2021 Apr 23;10(5):361. doi: 10.3390/biology10050361.
10
ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.ELAVL1a 是一种免疫功能蛋白，可保护斑马鱼胚胎免受细菌感染。
Commun Biol. 2021 Feb 26;4(1):251. doi: 10.1038/s42003-021-01777-z.
本文引用的文献
1
ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system.ELAV蛋白在一种新型的体外mRNA去腺苷酸化/降解系统中稳定去腺苷酸化中间体。
Genes Dev. 1999 Jan 15;13(2):188-201. doi: 10.1101/gad.13.2.188.
2
HNS, a nuclear-cytoplasmic shuttling sequence in HuR.HNS，HuR中的一个核质穿梭序列。
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15293-8. doi: 10.1073/pnas.95.26.15293.
3
Nuclear RNA export.核RNA输出
Genes Dev. 1998 Nov 1;12(21):3303-19. doi: 10.1101/gad.12.21.3303.
4
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.ELAV蛋白HuA（HuR）可在细胞核与细胞质之间重新分布，且在血清刺激和T细胞活化过程中上调。
J Cell Sci. 1998 Nov;111 ( Pt 21):3145-56. doi: 10.1242/jcs.111.21.3145.
5
RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein.富含AU元件结合蛋白HuR（一种ELAV蛋白）对RNA的稳定作用。
EMBO J. 1998 Jun 15;17(12):3461-70. doi: 10.1093/emboj/17.12.3461.
6
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs.HuR是一种穿梭于细胞核与细胞质之间的蛋白质，其过表达可提高含ARE的mRNA在体内的稳定性。
EMBO J. 1998 Jun 15;17(12):3448-60. doi: 10.1093/emboj/17.12.3448.
7
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR.RNA结合蛋白HuR对血管内皮生长因子mRNA的低氧稳定作用。
J Biol Chem. 1998 Mar 13;273(11):6417-23. doi: 10.1074/jbc.273.11.6417.
8
Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus.包含人类ELAV蛋白的信使核糖核蛋白复合物：与细胞骨架和翻译装置的相互作用
J Cell Sci. 1998 Jan;111 ( Pt 2):183-97. doi: 10.1242/jcs.111.2.183.
9
AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation.富含AU元件将小核RNA以及信使核糖核酸作为快速降解的目标。
Genes Dev. 1997 Oct 1;11(19):2557-68. doi: 10.1101/gad.11.19.2557.
10
Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression.参与生长、分化和转录后基因表达的胚胎致死性异常视觉RNA结合蛋白。
Am J Hum Genet. 1997 Aug;61(2):273-8. doi: 10.1086/514866.
Zotero 插件