局部mRNA核糖核蛋白颗粒的核内起源与胞质性质

The nuclear nurture and cytoplasmic nature of localized mRNPs.

作者信息

Giorgi Corinna, Moore Melissa J

机构信息

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA.

出版信息

Semin Cell Dev Biol. 2007 Apr;18(2):186-93. doi: 10.1016/j.semcdb.2007.01.002. Epub 2007 Jan 23.

DOI:10.1016/j.semcdb.2007.01.002

PMID:17459736

Abstract

From yeast to mammals, evidence has emerged in recent years highlighting the essential role played by the nuclear "history" of a messenger RNA in determining its cytoplasmic fate. mRNA localization, translation and stability in the cytoplasm are often pre-destined in the nucleus, and directed by the composition and architecture of nuclear assembled mRNA-protein complexes. In this review we focus on nuclear-acquired RNA-binding proteins and complexes that participate in determining the journey of localized mRNAs.

摘要

从酵母到哺乳动物，近年来有证据表明，信使核糖核酸（mRNA）的核“历史”在决定其细胞质命运方面发挥着重要作用。mRNA在细胞质中的定位、翻译和稳定性通常在细胞核中就已预先确定，并由核组装的mRNA-蛋白质复合物的组成和结构所指导。在这篇综述中，我们重点关注参与决定局部化mRNA行程的核获得性RNA结合蛋白和复合物。