Schnapp D, Reid C J, Harris A
Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, U.K.
J Pathol. 1998 Sep;186(1):99-103. doi: 10.1002/(SICI)1096-9896(199809)186:1<99::AID-PATH133>3.0.CO;2-#.
Defensins are antimicrobial peptides which play a key role in innate immunity. High levels of human beta defensin-1 (hBD-1) have previously been detected in the kidney and pancreas, but the cell-specific location of hBD-1 mRNA has not been determined. The expression of hBD-1 mRNA has been examined in fetal and adult pancreas and kidney by mRNA in situ hybridization. In fetal pancreas, hBD-1 expression was detected in the developing acini and in adult pancreas in the acini, but not in the pancreatic ducts. In both fetal and adult kidney, hBD-1 expression was detected in the collecting ducts and in the loops of Henle in adult kidney. Expression of hBD-1 mRNA in the pancreas and kidney from early development and in the acini of the adult pancreas, rather than in the pancreatic ducts, may indicate that in these tissues, hBD-1 fulfils physiological functions in addition to host defence.
防御素是一类抗菌肽，在固有免疫中发挥关键作用。此前已在肾脏和胰腺中检测到高水平的人β-防御素-1（hBD-1），但hBD-1 mRNA的细胞特异性定位尚未确定。通过mRNA原位杂交技术，对胎儿及成人的胰腺和肾脏中hBD-1 mRNA的表达情况进行了检测。在胎儿胰腺中，hBD-1表达于发育中的腺泡；在成人胰腺中，hBD-1表达于腺泡，但在胰管中未检测到。在胎儿和成人肾脏中，hBD-1均表达于集合管以及成人肾脏的髓袢。hBD-1 mRNA在早期发育阶段的胰腺和肾脏以及成人胰腺腺泡中表达，而非在胰管中表达，这可能表明在这些组织中，hBD-1除了具有宿主防御功能外，还发挥着生理功能。
