Jang D S, Yang M S, Ha T J, Park K H
Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea.
Arch Pharm Res. 1998 Oct;21(5):591-4. doi: 10.1007/BF02975380.
The structural analogues of cumambrin B (1, 2, 3, 4) were isolated from the flower of Chrysanthemum boreale Makino. The structures of compounds were determined by two-dimensional 1H-1H COSY and 13C-1H COSY spectra with the aid of homonuclear and heteronuclear double resonance experiment. The stereochemistry of compounds has been verified from single crystal X-ray diffraction of cumambrin A (2). The antimicrobial activities of these guaianolides have been studied.
从北野菊的花中分离出了补骨脂内酯B（1、2、3、4）的结构类似物。借助同核和异核双共振实验，通过二维氢-氢化学位移相关谱（1H-1H COSY）和碳-氢化学位移相关谱（13C-1H COSY）确定了化合物的结构。通过补骨脂内酯A（2）的单晶X射线衍射验证了化合物的立体化学。对这些愈创木烷型倍半萜内酯的抗菌活性进行了研究。
