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多样伞形内酯A - G,来源于歧伞阿魏根中的愈创木内酯类化合物。

Diversolides A-G, guaianolides from the roots of Ferula diversivittata.

作者信息

Iranshahi Mehrdad, Hosseini Seyyed Tahmineh, Shahverdi Ahmad Reza, Molazade Kamyar, Khan Saleha Suleman, Ahmad Viqar Uddin

机构信息

Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Boulevard, Mashhad, Iran.

出版信息

Phytochemistry. 2008 Nov;69(15):2753-7. doi: 10.1016/j.phytochem.2008.08.009. Epub 2008 Sep 18.

Abstract

Seven sesquiterpene lactone derivatives, diversolides A-G (1-7), together with two known compounds, diversin (8) and stigmasterol, were isolated from the roots of Ferula diversivittata. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-(1H and 13C) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC, and NOESY) as well as high-resolution EIMS. Compounds 1, 4 and 6-8 were tested for their in vitro antifungal and antibacterial activities. Some of the tested compounds showed moderate antifungal and antibacterial activities with minimum inhibitory concentration (MIC) values from 40 to 80microg/ml.

摘要

从歧茎阿魏的根部分离得到了7种倍半萜内酯衍生物,即歧茎内酯A-G(1-7),以及两种已知化合物,歧茎素(8)和豆甾醇。通过广泛的光谱方法,包括一维(1H和13C)和二维核磁共振实验(DQF-COSY、HSQC、HMBC和NOESY)以及高分辨率电子轰击质谱法,阐明了这些化合物的结构。对化合物1、4和6-8进行了体外抗真菌和抗菌活性测试。一些受试化合物表现出中等的抗真菌和抗菌活性,最低抑菌浓度(MIC)值为40至80微克/毫升。

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