Cho J Y, Park J, Yoo E S, Yoshikawa K, Baik K U, Lee J, Park M H
R & D Center, Daewoong Pharm. Co. Ltd., Sungnam, Kyunggi-Do, Korea.
Arch Pharm Res. 1998 Feb;21(1):12-6. doi: 10.1007/BF03216746.
The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-alpha production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 micrograms/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-alpha production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-alpha production.
研究了从日本黄连变种根茎中分离出的10种木脂素成分对脂多糖（LPS）刺激的巨噬细胞系（RAW264.7细胞）中肿瘤坏死因子（TNF）-α产生的抑制作用。其中，松脂醇、吴茱萸苷-V和落叶松脂醇糖苷在浓度为25微克/毫升时显示出37%至55%的显著抑制活性。这些结果首次报道了从日本黄连中分离出的木脂素抑制TNF-α的产生，并表明木脂素成分可能通过抑制TNF-α的产生部分参与日本黄连的抗炎和抗过敏作用。
