Cho J Y, Kim A R, Park M H
Department of Immunopharmacology, R & D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam, Korea.
Planta Med. 2001 Jun;67(4):312-6. doi: 10.1055/s-2001-14322.
Coptis japonica Makino (Ranunculaceae) is known to possess several biological activities such as anti-inflammatory effects. In this study, five lignans, isolariciresinol (1), lariciresinol glycoside (2), pinoresinol (3), pinoresinol glycoside (4) and syringaresinol glycoside (5), isolated from the rhizomes of C. japonica were tested to evaluate their in vitro anti-inflammatory effects. Pinoresinol and isolariciresinol showed higher inhibitory effects on TNF-alpha production, whereas syringaresinol glycoside strongly suppressed lymphocyte proliferation. The results indicate that the lignans may differentially modulate inflammatory cell responses, suggesting that these compounds may participate in anti-inflammatory processes by C. japonica.
黄连（毛茛科）已知具有多种生物活性，如抗炎作用。在本研究中，对从黄连根茎中分离出的五种木脂素，即异落叶松脂醇（1）、落叶松脂醇糖苷（2）、松脂醇（3）、松脂醇糖苷（4）和紫丁香树脂醇糖苷（5）进行了测试，以评估它们的体外抗炎作用。松脂醇和异落叶松脂醇对肿瘤坏死因子-α的产生表现出较高的抑制作用，而紫丁香树脂醇糖苷则强烈抑制淋巴细胞增殖。结果表明，这些木脂素可能对炎症细胞反应有不同的调节作用，提示这些化合物可能参与了黄连的抗炎过程。
