Vaamonde C A, Michael U F, Oster J R, Sebastianelli M J, Vaamonde L S, Klingler E L, Papper S
Nephron. 1976;17(5):382-95. doi: 10.1159/000180744.
The renal concentrating ability was studied in ten patients with hypothyroidism and in 15 euthyroid controls. Solute-free water reabsorption was reduced in the patients with myxedema (4.2 +/- 0.3 ml/min: controls 5.8 +/- 0.6 ml/min; p less than 0.01). This defect was apparent at high rates of solute excretion, and was associated with enhanced excretion of sodium (p less than 0.01) despite a decreased filtered load (p less than 0.005). The myxedema patients had a modest reduction in maximal urine osmolality (p less than 0.04), which was entirely attributable to the lower values observed in younger patients. The results may be explained best by decreased sodium chloride reabsorption in the ascending limb of Henle's loop and/or diminished permeability of the distal nephron in myxedema.
对10例甲状腺功能减退患者和15例甲状腺功能正常的对照者的肾脏浓缩能力进行了研究。黏液性水肿患者的无溶质水重吸收减少（4.2±0.3毫升/分钟：对照组为5.8±0.6毫升/分钟；p<0.01）。这种缺陷在高溶质排泄率时明显，并且尽管滤过负荷降低（p<0.005），但与钠排泄增加相关（p<0.01）。黏液性水肿患者的最大尿渗透压有适度降低（p<0.04），这完全归因于年轻患者中观察到的较低值。结果最好用髓袢升支中氯化钠重吸收减少和/或黏液性水肿中远端肾单位通透性降低来解释。
