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The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.

作者信息

Roks G, Cruts M, Bullido M J, Backhovens H, Artiga M J, Hofman A, Valdivieso F, Van Broeckhoven C, Van Duijn C M

机构信息

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

出版信息

Neurosci Lett. 1998 Dec 18;258(2):65-8. doi: 10.1016/s0304-3940(98)00857-x.

DOI:10.1016/s0304-3940(98)00857-x
PMID:9875528
Abstract

The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.

摘要

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1
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
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2
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引用本文的文献

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2
A comprehensive genetic association study of Alzheimer disease in African Americans.一项针对非裔美国人阿尔茨海默病的全面基因关联研究。
Arch Neurol. 2011 Dec;68(12):1569-79. doi: 10.1001/archneurol.2011.646.
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Genetic studies in Alzheimer's disease.
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Dialogues Clin Neurosci. 2003 Mar;5(1):17-26. doi: 10.31887/DCNS.2003.5.1/yptang.
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Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.鉴定人载脂蛋白 E 启动子序列中三个单核苷酸多态性的功能：对神经元细胞和 DNA-蛋白质相互作用的影响。
Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):185-201. doi: 10.1002/ajmg.b.30973.
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