Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia,
Neurochem Res. 2014 Feb;39(2):244-7. doi: 10.1007/s11064-013-1213-y. Epub 2013 Dec 11.
The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer's disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position -491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the potential involvement of this polymorphism as a risk factor for AD, either through an independent effect or through interaction with the existing APOE ε4 allele risk. The T allele frequency was significantly higher in the AD patients group (45.3 %) than in the controls group (32.78 %) and may possibly constitute a significant risk factor for AD. The APOE ε4 allele did not influence the distribution of the -491 polymorphism after stratification.
载脂蛋白 E（APOE）是晚发性阿尔茨海默病（AD）的一个既定的风险因素。多项研究试图证实位于 APOE 基因转录调控区的位置-491 处的多态性与 AD 之间的关联。我们在 85 名 AD 患者和 90 名来自突尼斯人群的对照者中研究了该多态性作为 AD 的风险因素的潜在作用，无论是通过独立效应还是通过与现有的 APOE ε4 等位基因风险的相互作用。在 AD 患者组（45.3％）中，T 等位基因频率明显高于对照组（32.78％），可能是 AD 的一个重要风险因素。在分层后，APOE ε4 等位基因并不影响-491 多态性的分布。
