褪黑素对幽门结扎大鼠胃酸和胃蛋白酶分泌的中枢神经系统作用
Central nervous system action of melatonin on gastric acid and pepsin secretion in pylorus-ligated rats.
作者信息
Kato K, Murai I, Asai S, Takahashi Y, Matsuno Y, Komuro S, Kurosaka H, Iwasaki A, Ishikawa K, Arakawa Y
机构信息
3rd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Neuroreport. 1998 Dec 1;9(17):3989-92. doi: 10.1097/00001756-199812010-00040.
We recently demonstrated that centrally administered melatonin at low doses inhibits the induction of gastric lesions by water-immersion restraint stress. To investigate the mechanism of the potent anti-ulcer action of melatonin, the central nervous system (CNS) effects of melatonin on gastric acid and pepsin secretion were studied in conscious pylorus-ligated rats. Intracisternal (i.c.) melatonin (1-100 ng) dose-dependently decreased acid and pepsin output, while a higher i.p. dose (1 microg) had no inhibitory effect. The i.c. melatonin did not change serum gastrin concentrations. Serum melatonin concentrations at 1 and 4 h after i.c. administration of 10-100 ng melatonin did not differ from those in rats receiving i.c. vehicle. The present results suggest that melatonin administered centrally modulates the secretion of gastric acid and pepsin which may explain, at least in part, the protective, anti-stress role of melatonin in the gastric mucosa observed in our previous study.
我们最近证明，低剂量中枢给予褪黑素可抑制水浸束缚应激诱导的胃损伤。为研究褪黑素强大的抗溃疡作用机制，我们在清醒的幽门结扎大鼠中研究了褪黑素对胃酸和胃蛋白酶分泌的中枢神经系统（CNS）效应。脑池内（i.c.）给予褪黑素（1-100 ng）可剂量依赖性地降低胃酸和胃蛋白酶分泌量，而较高的腹腔注射剂量（1 μg）则无抑制作用。脑池内给予褪黑素不会改变血清胃泌素浓度。脑池内给予10-100 ng褪黑素后1小时和4小时的血清褪黑素浓度与接受脑池内注射赋形剂的大鼠无差异。目前的结果表明，中枢给予褪黑素可调节胃酸和胃蛋白酶的分泌，这可能至少部分解释了我们之前研究中观察到的褪黑素在胃黏膜中的保护、抗应激作用。
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