Nussinovitch M, Prais D, Finkelstein Y, Varsano I
Department of Pediatrics, Schneider Children's Medical Center of Israel, Petah Tikva.
Pediatr Dermatol. 1998 Nov-Dec;15(6):426-8. doi: 10.1046/j.1525-1470.1998.1998015426.x.
We evaluated the anatomic distribution and pattern of skin involvement in 155 pediatric patients with Henoch-Schönlein purpura treated in our center over the last 20 years. Of these, 120 (77.4%) presented with cutaneous signs; only 10% of them had no leg involvement. Seven patients (4.5%) had edema of the hands, feet, or face. The mean age of this subgroup was 9.2+/-2.2 months, compared to 6.8+/-2.3 years for the entire group (p < 0.05). Skin biopsies were performed in 18 of these patients, including the 7 with edema, to confirm the clinical diagnosis. All biopsy specimens showed leukocytoclastic vasculitis, with IgA deposits in two and C3 deposits in one. It is important that clinicians keep in mind that an atypical presentation of Henoch-Schönlein purpura is not unusual.
我们评估了过去20年在我们中心接受治疗的155例小儿过敏性紫癜患者皮肤受累的解剖分布和模式。其中，120例（77.4%）出现皮肤症状；其中只有10%没有腿部受累。7例（4.5%）出现手、足或面部水肿。该亚组的平均年龄为9.2±2.2个月，而整个组的平均年龄为6.8±2.3岁（p<0.05）。对其中18例患者进行了皮肤活检，包括7例有水肿的患者，以确诊临床诊断。所有活检标本均显示白细胞破碎性血管炎，2例有IgA沉积，1例有C3沉积。临床医生必须牢记，过敏性紫癜的非典型表现并不罕见。
