Omidi C J, Siegfried E C
Department of Dermatology, St. Louis University Health Sciences Center, Missouri 63104, USA.
Pediatr Dermatol. 1998 Nov-Dec;15(6):435-8. doi: 10.1046/j.1525-1470.1998.1998015435.x.
Chronic recurrent multifocal osteomyelitis (CRMO) is a clinicopathologic entity of unknown origin mainly affecting children and young adults. It shares many clinical features with pyoderma gangrenosum (PG), an uncommon ulcerating inflammatory disorder of the dermis and underlying subcutaneous fat. Both conditions are chronic and relapsing, and have been associated with inflammatory bowel disease (IBD). The diagnoses are made by exclusion. Histology is nonspecific and cultures are negative. There has been only one previous report of both conditions occurring in the same patient. Here we describe the second case, a 12-year-old girl who developed pyoderma gangrenosum in direct continuity to an underlying CRMO lesion of the right anterior tibia. Occult ulcerative colitis (UC) was subsequently discovered.
慢性复发性多灶性骨髓炎（CRMO）是一种病因不明的临床病理实体，主要影响儿童和年轻人。它与坏疽性脓皮病（PG）有许多临床特征，PG是一种罕见的真皮和皮下脂肪溃疡性炎症性疾病。这两种疾病都是慢性复发性的，并且都与炎症性肠病（IBD）有关。诊断是通过排除法做出的。组织学表现非特异性，培养结果为阴性。此前仅有一份关于同一患者同时发生这两种疾病的报告。在此我们描述第二例病例，一名12岁女孩，其坏疽性脓皮病与右胫骨前下方潜在的CRMO病变直接相连。随后发现了隐匿性溃疡性结肠炎（UC）。
