Matteelli A, Signorini L, Tebaldi A, Bombana E, Chatel G, Pinsi G
Clinic of Infectious and Tropical Diseases-University of Brescia, Italy.
J Chemother. 1998 Dec;10(6):474-5. doi: 10.1179/joc.1998.10.6.474.
Macrolide resistance in disseminated Mycobacterium avium infection is of major concern in AIDS patients as these drugs represent the main component of combination therapy. Clarithromycin and azithromycin should not be used alone for the treatment and prophylaxis of the disease because of the risk of selecting resistant strains. We report the case of a clarithromycin resistant disseminated M. avium infection in an AIDS patient, acquired after long term monotherapy with clarithromycin for the treatment of cryptosporidiosis.
在播散性鸟分枝杆菌感染中，大环内酯类耐药性是艾滋病患者主要关注的问题，因为这些药物是联合治疗的主要组成部分。由于存在选择耐药菌株的风险，克拉霉素和阿奇霉素不应单独用于该疾病的治疗和预防。我们报告了一例艾滋病患者发生克拉霉素耐药的播散性鸟分枝杆菌感染病例，该患者在长期使用克拉霉素单药治疗隐孢子虫病后感染。
