Bouchiat C, Wang M D, Allemand J, Strick T, Block S M, Croquette V
LPT, ENS, Laboratoire propre du CNRS, Paris, France.
Biophys J. 1999 Jan;76(1 Pt 1):409-13. doi: 10.1016/s0006-3495(99)77207-3.
We describe a simple computation of the worm-like chain model and obtain the corresponding force-versus-extension curve. We propose an improvement to the Marko and Siggia interpolation formula of Bustamante et al (Science 1994, 265:1599-1600) that is useful for fitting experimental data. We apply it to the experimental elasticity curve of single DNA molecules. Finally, we present a tool to study the agreement between the worm-like chain model and experiments.
我们描述了蠕虫状链模型的一种简单计算方法,并得到了相应的力-伸长曲线。我们对Bustamante等人(《科学》,1994年,265卷:1599 - 1600页)的Marko和Siggia插值公式提出了一种改进方法,该方法有助于拟合实验数据。我们将其应用于单个DNA分子的实验弹性曲线。最后,我们展示了一种工具,用于研究蠕虫状链模型与实验之间的一致性。