Safieh-Garabedian B, Kanaan S A, Jabbur S J, Saadé N E
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon.
Neuroimmunomodulation. 1999 Jan-Apr;6(1-2):39-44. doi: 10.1159/000026362.
Thymulin is a thymic hormone with known immunomodulatory activities. Recent evidence has indicated a signaling role for this peptide in the interaction between the immune, endocrine and the nervous system. In this report, we review recent experimental findings on the analgesic actions of thymulin (high doses) in rats with endotoxin-induced localized inflammation and the hyperalgesic actions (low doses) of this peptide in intact animals. These actions involve both proinflammatory cytokines and PGE2. The possibility of a dual role played by thymulin as a hormone that might also involve a direct effect on the nervous system is discussed.
胸腺素是一种具有已知免疫调节活性的胸腺激素。最近的证据表明，这种肽在免疫、内分泌和神经系统之间的相互作用中具有信号传导作用。在本报告中，我们综述了关于胸腺素（高剂量）对内毒素诱导的局部炎症大鼠的镇痛作用以及该肽对完整动物的痛觉过敏作用（低剂量）的最新实验发现。这些作用涉及促炎细胞因子和前列腺素E2。我们还讨论了胸腺素作为一种激素可能发挥双重作用的可能性，这可能还涉及对神经系统的直接影响。
