Brown G P, Courtney G A, Marotta S F
Steroids. 1976 Aug;28(2):283-94. doi: 10.1016/0039-128x(76)90116-1.
Adrenal secretory rates and peripheral plasma levels of progesterone (PROG) were determined during the estrous cycles of hamsters and 4-day cyclic rats. In both species, the PROG concentrations in peripheral plasma were never more than 6% of those observed in adrenal venous plasma. In hamsters, adrenal PROG secretory rates varied from 3.8 +/- 0.8 ng/min at 0800 hr on proestrus (P) to 8.5 +/- 1 ng/min at 2000 hr on estrus (E). The rates noted on P were among the lowest observed and were similar to those noted at 0800 hr the following morning. In rats, adrenal PROG secretory rates varied from 57 +/- 9 ng/min at 0800 hr on E to 130 +/- 18 ng/min at 2000 hr on P. A significant decline occurred between 2000 hr on P and 0800 hr the following morning. Rats secreted 3 to 8 times more PROG than did hamsters when the secretory rates are expressed as ng/min/100 mg adrenal. In hamsters, the data suggest a relative lack of influence of female reproductive hormones on adrenal PROG secretion and in turn the latter may not be involved in reproductive hormonal changes leading to ovulation. In rats, the increased adrenal PROG secretion noted on P may be due to the influence of reproductive hormones on adrenocortical function. This elevated rate may in turn influence the hypothalamo-hypophyseal-ovarian axis.
在仓鼠和4天周期的大鼠发情周期中，测定了孕酮（PROG）的肾上腺分泌率和外周血浆水平。在这两个物种中，外周血浆中的PROG浓度从未超过肾上腺静脉血浆中观察到的浓度的6%。在仓鼠中，肾上腺PROG分泌率从发情前期（P）08:00时的3.8±0.8 ng/分钟变化到发情期（E）20:00时的8.5±1 ng/分钟。发情前期记录的分泌率是观察到的最低水平之一，与第二天早上08:00时记录的分泌率相似。在大鼠中，肾上腺PROG分泌率从发情期08:00时的57±9 ng/分钟变化到发情前期20:00时的130±18 ng/分钟。在发情前期20:00时到第二天早上08:00时之间出现了显著下降。当分泌率以ng/分钟/100毫克肾上腺表示时，大鼠分泌的PROG比仓鼠多3至8倍。在仓鼠中，数据表明雌性生殖激素对肾上腺PROG分泌的影响相对较小，反过来，后者可能不参与导致排卵的生殖激素变化。在大鼠中，发情前期观察到的肾上腺PROG分泌增加可能是由于生殖激素对肾上腺皮质功能的影响。这种升高的分泌率反过来可能会影响下丘脑-垂体-卵巢轴。
