Elsheikh M, Conway G S
Department of Endocrinology, Middlesex Hospital, London, UK.
Clin Endocrinol (Oxf). 1998 Oct;49(4):447-50. doi: 10.1046/j.1365-2265.1998.00552.x.
To evaluate risk factors for coronary artery disease in women with Turner's syndrome which may contribute to the increased incidence of premature cardiovascular death noted in this disorder.
Comparison of clinical and biochemical parameters in women with Turner's syndrome with those in women with normal karyotype.
Ninety-one women with Turner's syndrome attending a dedicated adult Turner's syndrome clinic and 22 control subjects were studied.
Recumbent blood pressure, body mass index (BMI), fasting total cholesterol, triglycerides and high density lipoproteins (HDL) were measured in both study groups.
Women with Turner's syndrome were more obese compared with women with a normal karyotype. They were more likely to be hypertensive and the obese patients had higher serum triglyceride concentrations. Hypertension was independent of obesity and may be under-recognized because of failure to compare with age-matched normal ranges. Lipoprotein changes were accounted for by the obesity.
Women with Turner's syndrome may be at increased risk of developing coronary artery disease as a result of the higher frequency of hypertension and obesity. Routine screening of this population for risk factors for ischaemic heart disease is recommended.
评估特纳综合征女性患冠状动脉疾病的风险因素，这些因素可能导致该疾病中过早心血管死亡发生率的增加。
将特纳综合征女性的临床和生化参数与核型正常女性的参数进行比较。
对91名前往成人特纳综合征专科诊所就诊的特纳综合征女性和22名对照受试者进行了研究。
在两个研究组中均测量了卧位血压、体重指数（BMI）、空腹总胆固醇、甘油三酯和高密度脂蛋白（HDL）。
与核型正常的女性相比，特纳综合征女性更肥胖。她们更易患高血压，且肥胖患者的血清甘油三酯浓度更高。高血压与肥胖无关，由于未与年龄匹配的正常范围进行比较，可能未得到充分认识。脂蛋白变化是由肥胖引起的。
由于高血压和肥胖的发生率较高，特纳综合征女性患冠状动脉疾病的风险可能增加。建议对该人群进行缺血性心脏病风险因素的常规筛查。
