Mitrevej A, Sinchaipanid N, Natpoolwat N, Naratikornrit N
Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Drug Dev Ind Pharm. 1998 Aug;24(8):793-6. doi: 10.3109/03639049809082728.
Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.
盐酸苯丙醇胺（PPA）微丸在流化床旋转制粒机中制备。微晶纤维素和蒸馏水分别用作制粒增强剂和粘合剂。微丸用甲基丙烯酸酯共聚物（Eudragit RS 100）溶液包衣，该溶液含有柠檬酸三乙酯和蓖麻油按1:1比例混合的混合物作为增塑剂。向50%的包衣微丸中添加约30%的微晶纤维素和2%的交联羧甲基纤维素钠制得快速崩解片。微丸及其相应的骨架片的溶出曲线具有可比性，且符合USP对PPA缓释胶囊的溶出要求。
