Sevgi F, Ozyazici M, Güneri T
University of Ege, Faculty of Pharmacy, Pharmaceutical Technology Department, Izmir, Turkey.
J Microencapsul. 1994 Jul-Aug;11(4):439-44. doi: 10.3109/02652049409034261.
In this study a 2(2) factorial design has been applied to the evaluation of dissolution characteristics of phenylpropranolamine hydrochloride (PPA.HCl) from tableted microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of two factors; drug particle size and kind of disintegrating agent, on the dissolution rate of PPA.HCl were studied at two levels. The factorial design method proved to be useful for the examination of tableted microcapsules.
在本研究中，采用2（2）析因设计来评估盐酸苯丙醇胺（PPA.HCl）从压制微囊中溶出的特性。根据罗辛-里姆勒-斯珀林-贝内特-韦布尔（RRSBW）分布的动力学模型用于溶出曲线的参数表示。研究了两个因素（药物粒径和崩解剂种类）在两个水平上对PPA.HCl溶出速率的影响。结果表明，析因设计方法对压制微囊的研究是有用的。
