Chen G L, Hao W H
Pharmaceutical Industry Technology and Development Center, Taipei, Taiwan, Republic of China.
Drug Dev Ind Pharm. 1998 Nov;24(11):1067-72. doi: 10.3109/03639049809089950.
Capsules filled with mixtures of verapamil, hydroxypropoxyl cellulose (HPC), and effervescent are proposed to provide floating sustained release over 10 hr. The effects of weight filled in the capsule, amount of HPC, and the addition of effervescent on the dissolution kinetics are studied. The conventional capsules were filled with different amounts and weights of the mixtures of verapamil, HPC, and effervescent. The release of verapamil from the capsules followed the Higuchi release model. However, when effervescent was added, a zero-order drug release was observed after the burst phase. The conventional capsule, when filled with active ingredients, polymers, and effervescent, can achieve a zero-order release system. Entrapped air was considered as a barrier to diffusion and matrix relaxation in drug release.
装有维拉帕米、羟丙基纤维素（HPC）和泡腾剂混合物的胶囊被提议用于提供超过10小时的漂浮缓释效果。研究了装入胶囊的重量、HPC的用量以及泡腾剂的添加对溶解动力学的影响。常规胶囊中装入了不同量和重量的维拉帕米、HPC和泡腾剂混合物。维拉帕米从胶囊中的释放遵循 Higuchi 释放模型。然而，当添加泡腾剂时，在爆发期后观察到零级药物释放。当常规胶囊填充有活性成分、聚合物和泡腾剂时，可以实现零级释放系统。截留的空气被认为是药物释放中扩散和基质松弛的障碍。
