Arora Shweta, Ali Javed, Ahuja Alka, Khar Roop K, Baboota Sanjula
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
AAPS PharmSciTech. 2005 Oct 19;6(3):E372-90. doi: 10.1208/pt060347.
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
撰写这篇关于漂浮药物递送系统(FDDS)综述的目的是汇编近期文献,特别关注实现胃滞留的漂浮主要机制。详细介绍了FDDS的最新进展,包括影响胃滞留的生理和制剂变量、单单元和多单元漂浮系统的设计方法及其分类和制剂方面。本综述还总结了体外技术、评估漂浮系统性能和应用的体内研究以及这些系统的应用。这些系统对药物剂型开发过程中遇到的几个问题很有用。