漂浮药物递送系统：综述
Floating drug delivery systems: a review.
作者信息
Arora Shweta, Ali Javed, Ahuja Alka, Khar Roop K, Baboota Sanjula
机构信息
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
出版信息
AAPS PharmSciTech. 2005 Oct 19;6(3):E372-90. doi: 10.1208/pt060347.
Abstract
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
摘要
撰写这篇关于漂浮药物递送系统（FDDS）综述的目的是汇编近期文献，特别关注实现胃滞留的漂浮主要机制。详细介绍了FDDS的最新进展，包括影响胃滞留的生理和制剂变量、单单元和多单元漂浮系统的设计方法及其分类和制剂方面。本综述还总结了体外技术、评估漂浮系统性能和应用的体内研究以及这些系统的应用。这些系统对药物剂型开发过程中遇到的几个问题很有用。
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本文引用的文献
1
The effect of density on the gastric emptying of single- and multiple-unit dosage forms.
Pharm Res. 1986 Aug;3(4):208-13. doi: 10.1023/A:1016334629169.
2
Morphology and buoyancy of oil-entrapped calcium pectinate gel beads.
AAPS J. 2004 Oct 7;6(3):e24. doi: 10.1208/aapsj060324.
3
Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation.
AAPS PharmSciTech. 2004 Apr 8;5(2):e34. doi: 10.1208/pt050234.
4
Preparation and evaluation of diltiazem hydrochloride-Gelucire 43/01 floating granules prepared by melt granulation.
AAPS PharmSciTech. 2004 Jul 12;5(3):e43. doi: 10.1208/pt050343.
5
Statistical optimization of gastric floating system for oral controlled delivery of calcium.
AAPS PharmSciTech. 2001 Jan 13;2(1):E1. doi: 10.1208/pt020101.
6
In vivo evaluation of riboflavin-containing microballoons for floating controlled drug delivery system in healthy human volunteers.
J Control Release. 2003 Nov 18;93(1):39-47. doi: 10.1016/s0168-3659(03)00370-5.
7
Floating dosage systems in drug delivery.
Crit Rev Ther Drug Carrier Syst. 2002;19(6):553-85. doi: 10.1615/critrevtherdrugcarriersyst.v19.i6.20.
8
Formulation and evaluation of sustained release floating capsules of nicardipine hydrochloride.
Pharmazie. 2003 Jan;58(1):38-43.
9
Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release.
Eur J Pharm Sci. 2003 Jan;18(1):37-45. doi: 10.1016/s0928-0987(02)00223-3.
10
Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres.
Int J Pharm. 2002 Dec 5;249(1-2):7-21. doi: 10.1016/s0378-5173(02)00396-4.
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