Carter P A, Rowley G, Fletcher E J, Stylianopoulos V
School of Health Sciences, University of Sunderland, Tyne and Wear.
Drug Dev Ind Pharm. 1998 Nov;24(11):1083-8. doi: 10.3109/03639049809089953.
The electrostatic charge generated on drug/excipient particles during the formulation, manufacture, and use of pharmaceutical dry powder inhaler (DPI) devices may significantly affect the performance of such devices. An experimental investigation has been undertaken of charge accumulation and decay on compacts of selected powders (lactose and salbutamol sulfate) and a device material (polyvinyl chloride, PVC) used during the formulation, manufacture, and use of DPIs. Significant differences in charge acquisition and decay for the three materials have been demonstrated after charging using a corona electrode. PVC acquired the highest charge, which decayed rapidly in 30 min toward the value prior to exposure to corona. Lactose and salbutamol acquired similar charge values, which decayed to zero after 30 min for lactose, whereas salbutamol retained a significant charge after 120 min. The significant differences in charging propensity among drug, excipient, and device materials may have relevance in DPI formulation, manufacture, and use.
在药用干粉吸入器（DPI）装置的配方、制造和使用过程中，药物/辅料颗粒上产生的静电荷可能会显著影响此类装置的性能。已对选定粉末（乳糖和硫酸沙丁胺醇）的压片以及DPI配方、制造和使用过程中使用的一种装置材料（聚氯乙烯，PVC）上的电荷积累和衰减进行了实验研究。使用电晕电极充电后，已证明这三种材料在电荷获取和衰减方面存在显著差异。PVC获取的电荷最高，在30分钟内迅速衰减至暴露于电晕之前的值。乳糖和硫酸沙丁胺醇获取的电荷值相似，乳糖在30分钟后衰减至零，而硫酸沙丁胺醇在120分钟后仍保留大量电荷。药物、辅料和装置材料之间充电倾向的显著差异可能与DPI的配方、制造和使用有关。
