Kerc J, Srcic S, Kofler B
Lek Pharmaceutical and Chemical Company d.d., Research and Development Division, Ljubljana, Slovenia.
Drug Dev Ind Pharm. 1998 Apr;24(4):359-63. doi: 10.3109/03639049809085631.
Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.
通过物理混合制备表面固体分散体，并在真空干燥器或微波炉中加热不同时间。使用差示扫描量热法和X射线粉末衍射法研究了固体分散体中费洛地平的物理状态。采用美国药典桨法进行费洛地平溶出度研究。真空或微波能量的使用使费洛地平的溶出度显著提高，这部分是由于费洛地平的无定形状态和无定形二氧化硅的大表面积所致。
