Webster J A, Dowse R, Walker R B
School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
Drug Dev Ind Pharm. 1998 Apr;24(4):395-9. doi: 10.3109/03639049809085636.
The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semi-synthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 +/- 8.18 and 99.66 +/- 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 +/- 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 +/- 0.27%).
采用美国药典旋转篮法研究了阿莫西林在不同亲脂性栓剂基质中的体外释放特性。在可可脂以及半合成基质Witepsol W35、Suppocire A32、Novata BD和Novata 299中制备了含250 mg阿莫西林的栓剂。对新制备的栓剂和保存1个月的栓剂均进行了测试。采用经过验证的高效液相色谱（HPLC）技术对阿莫西林进行分析。不同基质之间的释放曲线存在显著差异，新制备的和保存1个月的Novata BD基质释放的阿莫西林量最多（分别为87.57±8.18%和99.66±6.63%），新制备的可可脂栓剂（8.82±0.75%）和保存1个月的Suppocire A32栓剂（7.78±0.27%）释放的量最少。
