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Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy.甲氧氯普胺与昂丹司琼预防腹腔镜胆囊切除术后恶心呕吐的比较
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本文引用的文献

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Studies of drugs given before anaesthesia. I. A method of pre-operative assessment.
Br J Anaesth. 1962 Jul;34:458-63. doi: 10.1093/bja/34.7.458.
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Postanesthetic nausea and vomiting.麻醉后恶心呕吐
Anesthesiology. 1961 Sep-Oct;22:773-80. doi: 10.1097/00000542-196109000-00011.
3
Postoperative nausea and vomiting. IV. Factors related to postoperative nausea and vomiting.术后恶心呕吐。四、与术后恶心呕吐相关的因素。
Anesthesiology. 1960 Mar-Apr;21:186-93. doi: 10.1097/00000542-196003000-00009.
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Postoperative vomiting; some factors affecting its incidence.
Br J Anaesth. 1957 Mar;29(3):114-23. doi: 10.1093/bja/29.3.114.
5
A double-blind, placebo-controlled pilot study examining the effectiveness of intravenous ondansetron in the prevention of postoperative nausea and emesis.一项双盲、安慰剂对照的初步研究，旨在检验静脉注射昂丹司琼预防术后恶心和呕吐的有效性。
J Clin Anesth. 1993 Jan-Feb;5(1):22-9. doi: 10.1016/0952-8180(93)90083-q.
6
Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery.昂丹司琼与安慰剂预防门诊妇科手术女性术后恶心呕吐的比较。
Anesthesiology. 1993 Jan;78(1):21-8. doi: 10.1097/00000542-199301000-00005.
7
Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: randomized, double-blind comparison with metoclopramide.预防性使用昂丹司琼在腹腔镜手术中的止吐效果：与甲氧氯普胺的随机双盲比较。
Br J Anaesth. 1993 Dec;71(6):845-8. doi: 10.1093/bja/71.6.845.
8
Ondansetron reduces the incidence and severity of poststrabismus repair vomiting in children.昂丹司琼可降低儿童斜视矫正术后呕吐的发生率和严重程度。
Anesth Analg. 1994 Sep;79(3):486-9. doi: 10.1213/00000539-199409000-00014.
9
Ondansetron prevents postoperative nausea and vomiting in women outpatients.昂丹司琼可预防女性门诊患者术后恶心和呕吐。
Anesth Analg. 1994 Nov;79(5):845-51. doi: 10.1213/00000539-199411000-00005.
10
The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery.预防性使用昂丹司琼、氟哌利多、奋乃静和胃复安对预防妇科大手术后恶心呕吐的疗效。
Anesth Analg. 1995 Jul;81(1):139-43. doi: 10.1097/00000539-199507000-00028.

女性与男性腹腔镜术后呕吐情况：昂丹司琼与甲氧氯普胺预防性止吐作用的比较

Post-laparoscopic vomiting in females versus males: comparison of prophylactic antiemetic action of ondansetron versus metoclopramide.

作者信息

Dabbous A, Itani M, Kawas N, Karam V, Aouad M, Baraka A, Khoury S J, Khoury G

机构信息

Department of Anesthesiology, American University of Beirut Medical Center, Lebanon.

出版信息

JSLS. 1998 Jul-Sep;2(3):273-6.

PMID:9876753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3015295/
Abstract

BACKGROUND AND OBJECTIVES

The incidence of postoperative vomiting in patients undergoing laparoscopic cholecystectomy is compared in females versus males. The report also compares the prophylactic action of ondansetron versus metoclopramide.

METHODS

A total of 85 American Society of Anesthesiologists (ASA) I and II patients were enrolled in the study. Patients were divided into two groups according to sex: Group I 53 females, and Group II 32 males. After anaesthetic induction, subjects received intravenously either 4 mg ondansetron or 10 mg metoclopramide.

RESULTS

The incidence of vomiting as well as the frequency of emetic episodes over 24 hours were analyzed in each group using X2 analysis. Data analysis revealed a significantly higher incidence (P < 0.05) of postoperative emesis in females 10:53 (18.9%) as compared to males 0:32 (0%). In the male group, no patient vomited postoperatively, whether prophylactic ondansetron or metoclopramide was used. While the incidence of emesis in the female group was lower (P < 0.05) in the ondansetron group (17.6%) than the metoclopramide group (29.6%).

CONCLUSION

These results may indicate prophylactic antiemetic therapy in female patients undergoing laparoscopic cholecystectomy; ondansetron appears to be superior to metoclopramide.

摘要

背景与目的

比较接受腹腔镜胆囊切除术患者中女性与男性术后呕吐的发生率。本报告还比较了昂丹司琼与甲氧氯普胺的预防作用。

方法

共有85例美国麻醉医师协会（ASA）I级和II级患者纳入本研究。患者按性别分为两组：I组53例女性，II组32例男性。麻醉诱导后，受试者静脉注射4 mg昂丹司琼或10 mg甲氧氯普胺。

结果

采用X2分析每组24小时内呕吐发生率及呕吐发作频率。数据分析显示，女性术后呕吐发生率[10/53（18.9%）]显著高于男性[0/32（0%）]（P < 0.05）。在男性组中，无论使用预防性昂丹司琼还是甲氧氯普胺，术后均无患者呕吐。而女性组中，昂丹司琼组呕吐发生率（17.6%）低于甲氧氯普胺组（29.6%）（P < 0.05）。

结论

这些结果可能表明，接受腹腔镜胆囊切除术的女性患者需要预防性抗呕吐治疗；昂丹司琼似乎优于甲氧氯普胺。