Lebert F, Pasquier F, Souliez L, Petit H
Memory Disorders Unit, Centre Hospitalier Régional Universitaire, Lille, France.
Alzheimer Dis Assoc Disord. 1998 Dec;12(4):335-9. doi: 10.1097/00002093-199812000-00014.
At autopsy, frontotemporal dementia (FTD) account for up to 20% of degenerative dementia cases, although FTDs are underrecognized in memory clinics. FTDs are confused with Alzheimer disease (AD) or vascular dementia (VaD). These misdiagnosis may affect the results of AD pharmacological trials. The first manifestations of FTD are behavioral abnormalities. The aim of this study was to assess a behavioral scale of frontal lobe dysfunction and to determine a behavioral cutoff to diagnose early FTD and distinguish it from AD and VaD. The score of the behavioral frontotemporal lobe dysfunction assessment scale was higher in FTD than in other dementias (p < 0.0001). With a cutoff of 3 points on the scale, FTD patients were diagnosed with a specificity of 95% and sensitivity of 91%. Noncognitive symptoms known to be institutionalization factors could contribute to differences between etiologies of mild dementia.
尸检显示，额颞叶痴呆（FTD）占退行性痴呆病例的比例高达20%，尽管在记忆门诊中FTD未得到充分认识。FTD常与阿尔茨海默病（AD）或血管性痴呆（VaD）相混淆。这些误诊可能会影响AD药物试验的结果。FTD的首发症状是行为异常。本研究的目的是评估额叶功能障碍的行为量表，并确定诊断早期FTD以及将其与AD和VaD区分开来的行为临界值。FTD患者的行为额颞叶功能障碍评估量表得分高于其他痴呆患者（p < 0.0001）。量表得分以3分为临界值时，诊断FTD患者的特异性为95%，敏感性为91%。已知作为住院因素的非认知症状可能导致轻度痴呆病因之间的差异。
