Setzer A K, Slotnick B
Pennsylvania State University, Hershey Medical Center, PA 17033, USA.
Physiol Behav. 1998 Dec 1;65(3):479-87. doi: 10.1016/s0031-9384(98)00185-1.
The effects of 150, 350, and 400 mg/kg intraperitoneal 3-methylindole (3-MI) on anterograde transport of horseradish peroxidase from the olfactory epithelium to the olfactory bulb were investigated. In 400 mg/kg 3-MI-treated rats sacrificed after 7 days only about 2% of all glomeruli had normal levels of the reaction product, and most glomeruli had no detectable reaction product. Lower doses of 3-MI produced correspondingly less disruption of axonal transport, with savings located primarily in the ventral to midlateral and the ventromedial region of the bulb. There was a gradual recovery of bulbar connections in 12-, 22-, and 92-day survival rats. In all cases, the increase in axonal transport was greatest in glomeruli on the lateral, ventral, and ventromedial areas of the bulb, and least evident or absent on the dorsal and dorsomedial areas.
研究了腹腔注射150、350和400mg/kg 3-甲基吲哚（3-MI）对辣根过氧化物酶从嗅上皮向嗅球顺行运输的影响。在7天后处死的400mg/kg 3-MI处理的大鼠中，所有肾小球中只有约2%的反应产物水平正常，大多数肾小球没有可检测到的反应产物。较低剂量的3-MI对轴突运输的破坏相应较小，主要保存在嗅球腹侧至中外侧和腹内侧区域。在存活12天、22天和92天的大鼠中，嗅球连接逐渐恢复。在所有情况下，轴突运输的增加在嗅球外侧、腹侧和腹内侧区域的肾小球中最大，在背侧和背内侧区域最不明显或没有增加。
