Setzer A K, Slotnick B
Pennsylvania State University, Hershey Medical Center, PA 17033, USA.
Physiol Behav. 1998 Dec 1;65(3):489-96. doi: 10.1016/s0031-9384(98)00186-3.
Rats were tested on odor-detection tasks after treatment with 400 mg/kg of 3-methyl-indole. As revealed by anterograde transport of horseradish peroxidase from the olfactory epithelium to the olfactory bulb glomeruli, treatment produced a severe (>97%) loss in sensory input relative to untreated controls. In almost all cases, only glomeruli in a restricted ventromedial segment of the bulb contained control levels of reaction product. In Experiment 1, five of nine experimental rats were anosmic or severely hyposmic, but the remaining four rats were able to detect amyl acetate vapor. In Experiment 2, four of seven experimental rats were anosmic, but the remaining three were able to detect each of four different odors. Among all experimental rats, those that were anosmic had significantly fewer glomeruli with dense anterograde transport than did those that could smell. Among rats that could smell, performance accuracy was related to the number of glomeruli with reaction product.
用400mg/kg的3-甲基吲哚处理大鼠后，对其进行气味检测任务测试。辣根过氧化物酶从嗅上皮向嗅球小球的顺行运输显示，与未处理的对照组相比，该处理导致感觉输入严重丧失（>97%）。几乎在所有情况下，只有嗅球腹内侧受限节段的小球含有对照水平的反应产物。在实验1中，9只实验大鼠中有5只嗅觉缺失或严重嗅觉减退，但其余4只大鼠能够检测到乙酸戊酯蒸汽。在实验2中，7只实验大鼠中有4只嗅觉缺失，但其余3只能够检测到四种不同气味中的每一种。在所有实验大鼠中，嗅觉缺失的大鼠与能够闻到气味的大鼠相比，具有密集顺行运输的小球明显更少。在能够闻到气味的大鼠中，表现准确性与含有反应产物的小球数量有关。
