通过微神经电图测定的肌肉交感神经活动水平在胰岛素依赖型糖尿病中具有可重复性。

Microneurographically determined muscle sympathetic nerve activity levels are reproducible in insulin-dependent diabetes mellitus.

作者信息

Hoffman R P, Sinkey C A, Anderson E A

机构信息

Department of Pediatrics, Clinical Research and Cardiovascular Centers, University of Iowa College of Medicine, Iowa City, USA.

出版信息

J Diabetes Complications. 1998 Nov-Dec;12(6):307-10. doi: 10.1016/s1056-8727(98)00010-5.

DOI:10.1016/s1056-8727(98)00010-5

PMID:9877463

Abstract

Our objective was to determine whether microneurographically determined muscle sympathetic nerve activity (MSNA) levels are equally reproducible in control and insulin-dependent diabetes mellitus (IDDM) subjects. We used a retrospective review of MSNA levels in 14 IDDM and 16 control subjects who had at least two microneurographic studies in the last 8 years in our laboratory. Results showed mean MSNA levels were lower in IDDM (9.2+/-1.2 bursts/min) than in control subjects (16.8+/-1.7 bursts/min) (p<0.002) but mean within individual MSNA coefficients (IDDM: 47+/-8%; controls 30+/-5%) and ranges of variation (IDDM: 6.6+/-1.9; controls: 7.5+/-1.9 bursts/min) did not differ between IDDM and control subjects. Thus, microneurographically determined MSNA levels are equally reproducible in IDDM and controls subjects. These results confirm and substantiate our previous findings of diminished MSNA in IDDM subjects.

摘要

我们的目的是确定通过微神经图测定的肌肉交感神经活动（MSNA）水平在对照组和胰岛素依赖型糖尿病（IDDM）患者中是否具有同等的可重复性。我们回顾性分析了14例IDDM患者和16例对照者的MSNA水平，这些患者在过去8年里在我们实验室至少接受过两次微神经图检查。结果显示，IDDM患者的平均MSNA水平（9.2±1.2次/分钟）低于对照组（16.8±1.7次/分钟）（p<0.002），但IDDM患者个体内MSNA系数的平均值（47±8%）和变异范围（6.6±1.9）与对照组（30±5%和7.5±1.9次/分钟）并无差异。因此，通过微神经图测定的MSNA水平在IDDM患者和对照者中具有同等的可重复性。这些结果证实并支持了我们之前关于IDDM患者MSNA降低的发现。