铝对成年大鼠大脑中超氧化物歧化酶活性的影响。

Effect of aluminum on superoxide dismutase activity in the adult rat brain.

作者信息

Atienzar F, Desor D, Burnel D, Keller J M, Lehr P, Vasseur P

机构信息

University of Plymouth, Plymouth Environmental Research Centre, Biological Sciences, Devon, UK.

出版信息

Biol Trace Elem Res. 1998 Oct;65(1):19-30. doi: 10.1007/BF02784111.

DOI:10.1007/BF02784111

PMID:9877534

Abstract

Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu/Zn and Mn SOD activities in the gray matter of the cortex. High Al levels were found in the plasma, the spleen, and the liver of the treated animals in comparison to the controls, but not in the cortex homogenates (gray matter). In addition, Al induced a significant decrease in food ingestion and weight gain.

摘要

为研究腹腔注射15毫克铝（氯化铝）/千克体重，连续17天对雄性大鼠大脑（皮质）中超氧化物歧化酶（SOD）活性的影响，进行了此项实验。实验发现，对照组与实验组大鼠皮质灰质中的铜/锌超氧化物歧化酶和锰超氧化物歧化酶活性并无显著差异。与对照组相比，实验组大鼠的血浆、脾脏和肝脏中的铝含量较高，但皮质匀浆（灰质）中铝含量未出现此现象。此外，铝还导致大鼠食物摄入量和体重显著下降。