Turnbull M J, Watkins J W
Br J Pharmacol. 1976 Sep;58(1):27-35. doi: 10.1111/j.1476-5381.1976.tb07689.x.
A method is described for the determination of halothane-induced sleeping time in the rat. 2 The sleeping time exhibited a diurnal variation which was due, at least in part, to a change in the sensitivity of the central nervous system (CNS) to the anaesthetic. 3 Tolerance to halothane did not develop in rats repeatedly exposed to the anaesthetic over a period of over 48 hours. 4 Repeated sleeping time determinations have been used to follow changes in the sensitivity of the CNS to the anaesthetic occurring with time. 5 A tolerance to halothane was induced by pretreatment of rats with doses of amylobarbitone, pentobarbitone or meprobamate sufficient to keep animals anaesthetized for approximately 12 hours. This tolerance was followed by a period of halothane-hypersensitivity. 6 Halothane-tolerant animals awakened with higher brain halothane concentrations and were also tolerant to intracerebroventricularly administered pentobarbitone. 7 Halothane-hypertensive rats awakened with lower brain halothane concentrations and were also hypersensitivity to intracerebroventricularly administered pentobarbitone. 8 The possibility that the induction of cross-tolerance to halothane may be indicative of a drug's potential to produce dependence is discussed.
本文描述了一种测定大鼠中氟烷诱导睡眠时间的方法。2睡眠时间呈现出昼夜变化，这至少部分归因于中枢神经系统（CNS）对麻醉剂敏感性的变化。3在超过48小时的时间内反复暴露于麻醉剂的大鼠中，未出现对氟烷的耐受性。4反复测定睡眠时间已被用于追踪随着时间推移CNS对麻醉剂敏感性的变化。5用足以使动物麻醉约12小时的戊巴比妥、异戊巴比妥或甲丙氨酯剂量对大鼠进行预处理，可诱导其对氟烷产生耐受性。这种耐受性之后会出现一段时间的氟烷超敏反应。6对氟烷耐受的动物在脑内氟烷浓度较高时苏醒，并且对脑室内注射的戊巴比妥也具有耐受性。7对氟烷敏感的大鼠在脑内氟烷浓度较低时苏醒，并且对脑室内注射的戊巴比妥也超敏。8讨论了对氟烷产生交叉耐受性的诱导可能表明药物产生依赖性潜力的可能性。
