氟烷诱导的小鼠睡眠时间：苯二氮䓬类药物对其的影响

Halothane-induced sleeping time in the mouse: its modification by benzodiazepines.

作者信息

Chambers D M, Jefferson G C, Ruddick C A

出版信息

Eur J Pharmacol. 1978 Jul 15;50(2):103-12. doi: 10.1016/0014-2999(78)90004-3.

Abstract

The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the response of mice to halothane. To assess the usefulness of the test the effects of amphetamine, chlorpromazine, histamine, morphine, nikethamide, pentobarbitone and SKF 525A have been investigated. The interaction between 5 benzodiazepines and halothane has been studied in particular. Results from sleeping time experiments, measurements of body temperature and of brain halothane concentrations suggest that the halothane-benzodiazepine interaction is due to additive CNS depressant effects. It was found that nitrazepam and diazepam were clearly more potent than chlorodiazepoxide, medazepam and oxazepam in respect of their interactions with halothane.

摘要

本文描述了在何种条件下，氟烷诱导小鼠睡眠时间延长可被用作中枢作用药物的测试方法。与使用巴比妥类药物诱导催眠的方法相比，该测试因其实际优势而值得推荐；必须充分考虑小鼠对氟烷反应的昼夜变化。为评估该测试的实用性，研究了苯丙胺、氯丙嗪、组胺、吗啡、尼可刹米、戊巴比妥和SKF 525A的作用。特别研究了5种苯二氮䓬类药物与氟烷之间的相互作用。睡眠时间实验、体温测量和脑氟烷浓度测量结果表明，氟烷与苯二氮䓬类药物的相互作用是由于中枢神经系统抑制作用的叠加。结果发现，就与氟烷的相互作用而言，硝西泮和地西泮明显比氯氮卓、美达西泮和奥沙西泮更有效。