用呼吸道合胞病毒中和性人抗体Fab片段（Fab 19）筛选出的单克隆抗体抗性突变体在融合（F）糖蛋白上定义了一个独特的表位。
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.
作者信息
Crowe J E, Firestone C Y, Crim R, Beeler J A, Coelingh K L, Barbas C F, Burton D R, Chanock R M, Murphy B R
机构信息
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0720, USA.
出版信息
Virology. 1998 Dec 20;252(2):373-5. doi: 10.1006/viro.1998.9462.
PMID:9878616
Abstract
A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.
摘要
一种名为RSV Fab 19的重组人抗体片段可有效中和呼吸道合胞病毒（RSV）。在此，我们报告了对抗体逃逸突变体的序列分析结果，该分析确定了对于人源或鼠源RSV F中和抗体结合至关重要的F糖蛋白氨基酸。
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