• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用呼吸道合胞病毒中和性人抗体Fab片段（Fab 19）筛选出的单克隆抗体抗性突变体在融合（F）糖蛋白上定义了一个独特的表位。

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.

作者信息

Crowe J E, Firestone C Y, Crim R, Beeler J A, Coelingh K L, Barbas C F, Burton D R, Chanock R M, Murphy B R

机构信息

Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0720, USA.

出版信息

Virology. 1998 Dec 20;252(2):373-5. doi: 10.1006/viro.1998.9462.

DOI:10.1006/viro.1998.9462
PMID:9878616
Abstract

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.

摘要

一种名为RSV Fab 19的重组人抗体片段可有效中和呼吸道合胞病毒（RSV）。在此，我们报告了对抗体逃逸突变体的序列分析结果，该分析确定了对于人源或鼠源RSV F中和抗体结合至关重要的F糖蛋白氨基酸。

相似文献

1
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.用呼吸道合胞病毒中和性人抗体Fab片段（Fab 19）筛选出的单克隆抗体抗性突变体在融合（F）糖蛋白上定义了一个独特的表位。
Virology. 1998 Dec 20;252(2):373-5. doi: 10.1006/viro.1998.9462.
2
Variable resistance to palivizumab in cotton rats by respiratory syncytial virus mutants.呼吸道合胞病毒突变体对棉鼠中帕利珠单抗产生的可变抗性。
J Infect Dis. 2004 Dec 1;190(11):1941-6. doi: 10.1086/425515. Epub 2004 Oct 27.
3
Increased susceptibility of human respiratory syncytial virus to neutralization by anti-fusion protein antibodies on adaptation to replication in cell culture.人呼吸道合胞病毒在适应细胞培养复制后，对抗融合蛋白抗体中和作用的敏感性增加。
J Med Virol. 2007 Jun;79(6):829-37. doi: 10.1002/jmv.20892.
4
Human monoclonal antibodies isolated from spontaneous Epstein-Barr virus-transformed tumors of Hu-SPL-SCID mice and specific for fusion protein display broad neutralizing activity toward respiratory syncytial virus.从Hu-SPL-SCID小鼠的自发性爱泼斯坦-巴尔病毒转化肿瘤中分离出的、对融合蛋白具有特异性的人单克隆抗体，对呼吸道合胞病毒显示出广泛的中和活性。
J Infect Dis. 1999 Aug;180(2):268-77. doi: 10.1086/314876.
5
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization.针对呼吸道合胞病毒的超高效抗体：结合动力学和结合价对病毒中和作用的影响
J Mol Biol. 2005 Jul 1;350(1):126-44. doi: 10.1016/j.jmb.2005.04.049.
6
Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus.针对人呼吸道合胞病毒融合糖蛋白的中和性单克隆抗体所识别的两个抗原位点的特性分析
J Gen Virol. 1992 Sep;73 ( Pt 9):2225-34. doi: 10.1099/0022-1317-73-9-2225.
7
Characterization of neutralizing affinity-matured human respiratory syncytial virus F binding antibodies in the sub-picomolar affinity range.鉴定在皮摩尔亲和力范围内具有中和作用的人类呼吸道合胞病毒 F 结合抗体的亲和力成熟。
J Mol Recognit. 2012 Mar;25(3):136-46. doi: 10.1002/jmr.2149.
8
Intranasal immunization with a replication-deficient adenoviral vector expressing the fusion glycoprotein of respiratory syncytial virus elicits protective immunity in BALB/c mice.用表达呼吸道合胞病毒融合糖蛋白的复制缺陷型腺病毒载体进行鼻内免疫可在BALB/c小鼠中引发保护性免疫。
Biochem Biophys Res Commun. 2009 Apr 17;381(4):528-32. doi: 10.1016/j.bbrc.2009.02.075. Epub 2009 Feb 20.
9
Binding of neutralizing monoclonal antibodies to regions of the fusion protein of respiratory syncytial virus expressed in Escherichia coli.中和性单克隆抗体与在大肠杆菌中表达的呼吸道合胞病毒融合蛋白区域的结合。
J Gen Virol. 1993 Dec;74 ( Pt 12):2559-65. doi: 10.1099/0022-1317-74-12-2559.
10
Isolation of a neutralizing human RSV antibody from a dominant, non-neutralizing immune repertoire by epitope-blocked panning.通过表位阻断淘选从占主导地位的非中和性免疫库中分离出一种中和性人呼吸道合胞病毒抗体。
J Immunol. 1996 Jul 15;157(2):772-80.

引用本文的文献

1
Epidemiological and phylogenetic characterization of human respiratory syncytial virus associated with severe acute respiratory infections in paediatric patients from 2016 to 2023 in Hangzhou, China.2016年至2023年中国杭州儿科患者中与严重急性呼吸道感染相关的人呼吸道合胞病毒的流行病学和系统发育特征
Microb Genom. 2025 Aug;11(8). doi: 10.1099/mgen.0.001484.
2
Whole-Genome Sequencing and Genetic Diversity of Human Respiratory Syncytial Virus in Patients with Influenza-like Illness in Sicily (Italy) from 2017 to 2023.2017 年至 2023 年意大利西西里流感样疾病患者中人类呼吸道合胞病毒的全基因组测序和遗传多样性。
Viruses. 2024 May 26;16(6):851. doi: 10.3390/v16060851.
3
Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain.
转染色体奶牛来源的人源单克隆抗体通过识别血凝素头部结构域中的新型构象表位中和多种 H1 流感病毒亚型。
J Virol. 2020 Oct 27;94(22). doi: 10.1128/JVI.00945-20.
4
Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B.B型呼吸道合胞病毒DS-Cav1稳定化融合糖蛋白的晶体结构与免疫原性
Pathog Immun. 2019 Dec 11;4(2):294-323. doi: 10.20411/pai.v4i2.338. eCollection 2019.
5
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.一种强效的广谱中和人呼吸道合胞病毒抗体靶向融合糖蛋白的保守结构域 IV。
Nat Commun. 2019 Sep 12;10(1):4153. doi: 10.1038/s41467-019-12137-1.
6
Detection of ON1 and novel genotypes of human respiratory syncytial virus and emergence of palivizumab resistance in Lebanon.黎巴嫩人类呼吸道合胞病毒 ON1 型和新型别及其帕利珠单抗耐药性的出现。
PLoS One. 2019 Feb 21;14(2):e0212687. doi: 10.1371/journal.pone.0212687. eCollection 2019.
7
Sequence Analysis of the Fusion Protein Gene of Human Respiratory Syncytial Virus Circulating in China from 2003 to 2014.2003 年至 2014 年中国流行的人类呼吸道合胞病毒融合蛋白基因序列分析。
Sci Rep. 2018 Dec 4;8(1):17618. doi: 10.1038/s41598-018-35894-3.
8
Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset.与综合数据集内相关病毒相比，人呼吸道合胞病毒 F 糖蛋白的抗原性和序列变异性。
Vaccine. 2018 Oct 29;36(45):6660-6673. doi: 10.1016/j.vaccine.2018.09.056. Epub 2018 Oct 3.
9
Neutralizing epitopes of RSV and palivizumab resistance in Japan.日本呼吸道合胞病毒的中和表位及帕利珠单抗耐药性
Fukushima J Med Sci. 2017 Dec 19;63(3):127-134. doi: 10.5387/fms.2017-09. Epub 2017 Sep 1.
10
Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.呼吸道合胞病毒融合蛋白抗原位点II处非中和抗体竞争的结构基础
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6849-E6858. doi: 10.1073/pnas.1609449113. Epub 2016 Oct 17.