Okada F, Kase M, Shintomi Y
Psychopharmacology (Berl). 1978 Jul 19;58(3):235-40. doi: 10.1007/BF00427385.
Pupillographic studies were made of the reactions to light and near vision in 12 schizophrenic patients under long-term administration of psychotropic drugs. The results showed a significant reduction in the light reaction, while the near vision reaction was preserved. The pupillographic study revealed not only reduction in amplitude of the light reaction but also changes in dynamic aspects of the reaction, i.e., prolonged latency time, shortened constriction time, and half redilatation time after the light stimulus. The mechanisms underlying the dissociation between light reaction and near vision reaction induced by long-term administration of psychotropic drugs are obscure, but both the peripheral and central actions of these drugs may be involved.
对12名长期服用精神药物的精神分裂症患者进行了瞳孔描记研究，以观察他们对光和近视力的反应。结果显示，光反应显著降低，而近视力反应则得以保留。瞳孔描记研究不仅揭示了光反应幅度的降低，还发现了反应动态方面的变化，即光刺激后的潜伏期延长、收缩时间缩短和半复张时间缩短。长期服用精神药物引起的光反应和近视力反应分离的潜在机制尚不清楚，但这些药物的外周和中枢作用可能都与之有关。
