Joly-Guillou M L
Service de Bactériologie, Hôpital Louis-Mourier, Colombes.
Presse Med. 1998 Dec;27 Suppl 5:31-3.
Certain DNA blocks inserted into the chromosome of most Gram negative bacteria originated in pathogens found in plants. VIRULENCE-ANTIBIOTIC INTERACTIONS: During the invasive phase, the bacterial cell covers itself with adhesins which facilitate its adherence to tissues. The bacterial cell produces a fibronectin which protects its defense systems. Antibiotics favor bacterial resistance by increasing the expression of surface adhesins and fibronectin production. PENICILLIN RESISTANT PNEUMOCOCCI: Experimental models have demonstrated that mortality in mice and host resistance to pneumococcal infection are related to the type of capsule and not to antibiotic resistance. QUORUM SENSING: The bacterial inoculum regulates the production of virulence factors in vivo via quorum sensing. This regulation can play an important role in Pseudomonas aeruginosa infections. ACINETOBACTER BAUMANNI VIRULENCE: Long poorly understood, factors favoring A. baumanni virulence appear to result from bacterial production of IROMPs in the extracellular growth medium in response to iron depletion during the exponential growth phase.
某些插入大多数革兰氏阴性菌染色体中的DNA片段起源于植物病原体。毒力 - 抗生素相互作用：在侵袭阶段，细菌细胞表面覆盖有粘附素，便于其粘附于组织。细菌细胞产生一种纤连蛋白，可保护其防御系统。抗生素通过增加表面粘附素的表达和纤连蛋白的产生而促进细菌耐药性。耐青霉素肺炎球菌：实验模型表明，小鼠死亡率和宿主对肺炎球菌感染的抵抗力与荚膜类型有关，而非与抗生素耐药性有关。群体感应：细菌接种物通过群体感应在体内调节毒力因子的产生。这种调节在铜绿假单胞菌感染中可能起重要作用。鲍曼不动杆菌毒力：长期以来一直未被充分理解，有利于鲍曼不动杆菌毒力的因素似乎是由于细菌在指数生长期因铁缺乏而在细胞外生长培养基中产生铁调节外膜蛋白所致。
