Horsman M R, Nordsmark M, Overgaard J
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.
Strahlenther Onkol. 1998 Dec;174 Suppl 4:2-5.
There is now good evidence that the oxygenation status of certain types of human tumors plays an important role in determining the response of those tumors to therapy. More recent evidence suggests that oxygenation status can also influence local tumor aggressiveness and metastatic spread. As a consequence significant effort is being made to find relevant methods for assessing tumor oxygenation status and thereby allowing for the selection of patients that should be given additional/alternative therapies to improve response. In this paper we will review the importance of tumor oxygenation status and discuss the potential clinical methods for monitoring that are currently available.
现在有充分的证据表明，某些类型的人类肿瘤的氧合状态在决定这些肿瘤对治疗的反应中起着重要作用。最近的证据表明，氧合状态也会影响局部肿瘤的侵袭性和转移扩散。因此，人们正在付出巨大努力寻找评估肿瘤氧合状态的相关方法，从而能够选择那些应该接受额外/替代疗法以提高反应的患者。在本文中，我们将综述肿瘤氧合状态的重要性，并讨论目前可用的潜在临床监测方法。
