Vaupel P
Institute of Physiology and Pathophysiology, University of Mainz.
Strahlenther Onkol. 1990 Jun;166(6):377-86.
The objective of this article is to summarize current knowledge of oxygen supply to human tumors and of tumor tissue oxygenation, parameters which go hand in hand, and in turn critically determine the cellular metabolic microenvironment of human malignancies. A compilation of available data on these factors is presented. Though data on human tumors in situ are scarce and there may be significant errors associated with the technique used for measurements, experimental evidence is provided for the existence of a compromised and anisotropic oxygen supply to many tumor cells. Comparable to experimental rodent tumors, O2-depleted areas develop in many human malignancies which coincide with nutrient and energy deprivation, and with a hostile metabolic microenvironment. Significant variations in these relevant parameters have to be expected between different locations within the same tumor, at the same location at different times, and between individual tumors of the same grading and staging. Therefore, evaluation of the oxygenation status in individual tumors before therapy might be most beneficial for designing specifically tailored treatment protocols for individual subjects in order to improve tumor response to treatment.
本文的目的是总结目前关于人体肿瘤氧供应和肿瘤组织氧合的知识，这两个参数密切相关，进而决定性地影响人类恶性肿瘤的细胞代谢微环境。文中呈现了关于这些因素的现有数据汇编。尽管关于原位人体肿瘤的数据稀缺，且测量技术可能存在重大误差，但仍有实验证据表明许多肿瘤细胞存在氧供应受损和各向异性的情况。与实验性啮齿动物肿瘤类似，许多人类恶性肿瘤中会出现缺氧区域，这些区域与营养和能量剥夺以及恶劣的代谢微环境相吻合。在同一肿瘤的不同位置、不同时间的同一位置以及相同分级和分期的个体肿瘤之间，这些相关参数预计会有显著差异。因此，在治疗前评估个体肿瘤的氧合状态可能对为个体患者设计专门定制的治疗方案最为有益，从而提高肿瘤对治疗的反应。
