Kakinoki Y, Ohashi Y, Kato A, Tanaka A, Washio Y, Yamada K, Masamoto T, Nasako Y, Nakai Y, Nakai Y
Department of Otolaryngology, Osaka City University Medical School, Japan.
Acta Otolaryngol Suppl. 1998;538:152-5.
The aim of this study was to determine whether there is a difference in the specific IgE response to pollen exposure between asymptomatic and symptomatic subjects who were already sensitized to Japanese cedar pollen. Sixty-four subjects with detectable serum levels of cedar pollen-specific IgE, which were apparent even before the pollen season in 1997, were enrolled in the study. Thirty-five had typical symptoms of seasonal allergic rhinitis during the pollen season in 1997 (symptomatic group) and the remainder had no seasonal aggravation during the pollen season in 1997 (asymptomatic group). Serum samples were collected twice from each subject, before and during the pollen season in 1997, to determine specific IgE by the lumiward immunoassay system. In both groups, the serum levels of specific IgE during the pollen season were significantly higher than those before the pollen season, and the rates of seasonal increase in specific IgE did not differ significantly between the groups. In conclusion, the specific IgE response during the pollen season is not a hallmark of clinical allergy and does not discriminate between symptomatic and asymptomatic individuals sensitive to the pollen.
本研究的目的是确定对日本雪松花粉已致敏的无症状和有症状受试者在接触花粉后特异性IgE反应是否存在差异。64名血清中雪松花粉特异性IgE水平可检测到的受试者被纳入研究，其在1997年花粉季节开始前该水平就已明显存在。35名受试者在1997年花粉季节出现典型的季节性过敏性鼻炎症状（有症状组），其余受试者在1997年花粉季节无季节性加重情况（无症状组）。在1997年花粉季节前和期间，从每位受试者采集两次血清样本，通过发光免疫分析系统测定特异性IgE。两组中，花粉季节期间特异性IgE的血清水平均显著高于花粉季节前，且两组间特异性IgE的季节性升高率无显著差异。总之，花粉季节期间的特异性IgE反应并非临床过敏的标志，也无法区分对花粉敏感的有症状和无症状个体。
