Sato K, Nakazawa T, Sahashi N, Kochibe N
Department of Laboratory Sciences, School of Health Sciences, Gunma University, Japan.
Ann Allergy Asthma Immunol. 1997 Jul;79(1):57-61. doi: 10.1016/S1081-1206(10)63085-2.
There have been no detailed long-term observations of the relationship between specific IgE production and stimulation by various naturally occurring allergens.
This study was conducted to elucidate the yearly and seasonal changes of specific IgE antibody production to Japanese cedar pollen, an allergen of Japanese cedar pollinosis, in young adults.
The number of Japanese cedar pollen were counted over a period of 9 years. Changes in the percentages of antibody carriers to Japanese cedar pollen and mite were examined during these years. Changes in Japanese cedar pollen-specific IgE levels between a low exposure year and a high exposure year in individual subjects were also investigated.
From 1987 to 1995, the percentages of Japanese cedar pollen-IgE carriers varied from about 30% to 50% with the intensity of pollen stimulation, and carriers tended to increase yearly. The rates of anti-mite IgE carriers changed little. In the spring which is the pollen season, Japanese cedar pollen-IgE levels in low exposure years were weaker than those in high exposure years in individual subjects. Levels in autumn, which is not the pollen season, showed equivalent levels in both high and low exposure years. Anti-mite IgE levels in individual subjects varied little during these years.
A long-term follow-up study supported that Japanese cedar pollen-IgE production is mainly associated with the degree of allergen exposure.
对于特定IgE产生与各种天然存在的过敏原刺激之间的关系，尚未有详细的长期观察。
本研究旨在阐明年轻成年人中针对日本雪松花粉（日本雪松花粉症的一种过敏原）的特异性IgE抗体产生的年度和季节性变化。
在9年的时间里对日本雪松花粉数量进行计数。检查这些年中针对日本雪松花粉和螨虫的抗体携带者百分比的变化。还调查了个体受试者在低暴露年份和高暴露年份之间日本雪松花粉特异性IgE水平的变化。
1987年至1995年，日本雪松花粉-IgE携带者的百分比随花粉刺激强度在约30%至50%之间变化，且携带者数量有逐年增加的趋势。抗螨虫IgE携带者的比例变化不大。在作为花粉季节的春季，个体受试者在低暴露年份的日本雪松花粉-IgE水平低于高暴露年份。在并非花粉季节的秋季，高暴露年份和低暴露年份的水平相当。这些年中个体受试者的抗螨虫IgE水平变化不大。
一项长期随访研究支持日本雪松花粉-IgE的产生主要与过敏原暴露程度相关。
