Nakasu S, Nakajima M, Nakazawa T, Nakasu Y, Handa J
Department of Neurosurgery, Shiga University of Medical Science, Japan.
Brain Tumor Pathol. 1998;15(1):13-7. doi: 10.1007/BF02482095.
We examined the expression of the p53 and bcl-2 family in embolized meningiomas and investigated the interaction between them. p53 and its downstream effector p21 accumulated mainly in perinecrotic areas, where apoptosis was also observed. bcl-2 was often expressed in the areas distant from necrosis, whereas Bax was immunostained more intensely in the perinecrotic areas. Double staining for both p53 and Bcl-2 showed a reciprocal pattern. This appeared to be due to the down-regulation of Bcl-2 by p53. However, regulation of Bax by p53 was not distinct. The expression of p21 was not apparent 13 days after embolization, and apoptosis was observed until 6 days after embolization. The effect of embolization was most likely temporary, although growth arrest has been reported to persist for a long time in a limited number of embolized cases.
我们检测了栓塞性脑膜瘤中p53和bcl-2家族的表达，并研究了它们之间的相互作用。p53及其下游效应分子p21主要在坏死周边区域积聚，在该区域也观察到了细胞凋亡。bcl-2常在远离坏死的区域表达，而Bax在坏死周边区域的免疫染色更强。p53和Bcl-2的双重染色显示出相反的模式。这似乎是由于p53对Bcl-2的下调所致。然而，p53对Bax的调节并不明显。栓塞后13天p21的表达不明显，且在栓塞后6天仍可观察到细胞凋亡。尽管在少数栓塞病例中据报道生长停滞会持续很长时间，但栓塞的效果很可能是暂时的。
