采用基于人B细胞系的TOFE吸附抑制试验检测丙型肝炎病毒中和抗体。
TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies.
作者信息
Valli M B, Bertolini L, Manzin A, Clementi M, Carloni G
机构信息
Istituto di Medicina Sperimentale, Rome, Italy.
出版信息
Res Virol. 1998 Sep-Oct;149(5):331-3. doi: 10.1016/s0923-2516(99)89015-3.
PMID:9879614
Abstract
We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.
摘要
我们先前证明，源自正常人骨髓的人淋巴母细胞B细胞系（LCL）TOFE可被丙型肝炎病毒（HCV）感染。在本报告中，我们基于TOFE细胞开发了一种体外HCV吸附抑制试验，以揭示急性感染患者血清中中和抗体的存在。
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