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[下丘脑在条件反射和情绪行为中的作用。(1) 家兔行为模型及其分析方法]

[Participation of the hypothalamus in conditioning and emotional behavior. (1) Behavior model in rabbits and methods of its analysis].

作者信息

Yanaura S, Mineo K, Abe Y

出版信息

Nihon Yakurigaku Zasshi. 1976 Mar;72(2):237-48.

PMID:987969
Abstract

An attempt was made to induce conflict behavior in rabbits by conditioning under hypothalamic electrical stimulation. Behavioral analysis was performed using our newly devised technique which employs the use of a vibration apparatus fixed to head and waist, and a recording of various behavior. Conditioning was carried out by sensory stimuli flight behavior. Reinforcement was as follows: the CS used was flickering light photic (10 Hz, 10 musec.,) and acoustic (250 Hz, 15 dB) and UCS electrical stimulation (100 Hz, 1 msec., not exceeding 2 v) in the medial hypothalamic area and peri-fornix. The restrained animals were placed on a table in an acoustically isolated room with a discrete monotonous background noise. CRs were obtained within a short time as were responses: (1) During the autonomicsomatic responses, (2) continuous run and (3) non-continuous run. Data obtained during the non-continuous run represent a conflict-induced type of behavior which may be applied in studies related to the psychopharmacological actions of drugs.

摘要

尝试通过下丘脑电刺激条件反射诱导兔子出现冲突行为。使用我们新设计的技术进行行为分析,该技术采用固定在头部和腰部的振动装置,并记录各种行为。通过感觉刺激逃避行为进行条件反射。强化如下:所使用的条件刺激(CS)为闪烁光(10赫兹,10微秒)和声音(250赫兹,15分贝),非条件刺激(UCS)为下丘脑内侧区域和穹窿周围的电刺激(100赫兹,1毫秒,不超过2伏)。将受约束的动物放置在隔音室内的桌子上,背景噪音离散且单调。在短时间内获得了条件反应(CRs)以及如下反应:(1)自主神经 - 躯体反应期间,(2)持续奔跑和(3)非持续奔跑。在非持续奔跑期间获得的数据代表一种冲突诱导的行为类型,可应用于与药物心理药理学作用相关的研究。

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1
[Participation of the hypothalamus in conditioning and emotional behavior. (1) Behavior model in rabbits and methods of its analysis].[下丘脑在条件反射和情绪行为中的作用。(1) 家兔行为模型及其分析方法]
Nihon Yakurigaku Zasshi. 1976 Mar;72(2):237-48.
2
[Conditioning of emotional behavior caused by hypothalamic stimulation (3): The learned behavior caused by hypothalamic stimulation in rabbits].[下丘脑刺激引起的情绪行为条件反射(3):家兔下丘脑刺激引起的习得行为]
Nihon Yakurigaku Zasshi. 1976 Sep;72(6):745-52.
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[Conditioning of emotional behavior originating at the hypothalamus. (2) Effects of drugs on conflict-induced behavior models].
Nihon Yakurigaku Zasshi. 1976 Apr;72(3):351-61.
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[Conditioned reactions elaborated on the basis of reinforcement by hypothalamic stimulation].[基于下丘脑刺激强化作用所形成的条件反应]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Jul-Aug;29(4):715-21.
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Neurotoxic lesions of the dorsal hippocampus disrupt auditory-cued trace heart rate (fear) conditioning in rabbits.家兔背侧海马的神经毒性损伤会破坏听觉提示的痕迹性心率(恐惧)条件反射。
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[Hypothalamic neurons and defensive reflexes].[下丘脑神经元与防御反射]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 May-Jun;43(3):496-506.
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A twin study of the genetics of fear conditioning.恐惧条件反射遗传学的双生子研究。
Arch Gen Psychiatry. 2003 Jul;60(7):702-8. doi: 10.1001/archpsyc.60.7.702.
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[Conditioned reflex reproduction of evoked potentials during reinforcement by electrostimulation of the hypothalamus].[下丘脑电刺激强化过程中诱发电位的条件反射再现]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1975 Sep-Oct;25(5):995-1001.
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Fiziol Zh SSSR Im I M Sechenova. 1986 Feb;72(2):158-63.
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Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy.在癫痫的全身性 kainic 酸和杏仁核刺激模型中,恐惧条件反射受损。
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